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Evo 2: a language model for the genome

Evo 2 is a language model for DNA, trained on 9.3 trillion letters from bacteria to humans. With no task-specific training it predicts which mutations cause disease, and it can design whole genomes from scratch.

Genomics × AIPaper

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A ten-slide breakdown of Evo 2: how a genomic language model learns evolutionary constraint, predicts disease variants with zero fine-tuning, teaches itself biology from DNA alone, and turns generative to design genomes across all domains of life.

Read the paper: Genome modelling and design across all domains of life with Evo 2 (Nature, 2026).